教师基本信息：

姓名：郑鸿翔

职称：副研究员

电子邮箱：[email protected]

办公地点：欧美剧情av B605

研究方向：

生物信息学；计算生物学；群体遗传学；分子进化。

主要通过生物信息学方法，围绕线粒体基因组(mitochondrial DNA)进行人类进化遗传学和群体遗传学研究，涉及以下几个方面：1）人群的扩张、迁徙和所受到自然选择作用等进化历史；2）线粒体DNA变异在人类表型和疾病中的作用；3）跨物种线粒体DNA分子进化研究；4）核基因组中线粒体DNA插入序列研究。

个人简介：

2006年于欧美剧情av 获得生物技术学士学位，2012年于欧美剧情av 获得遗传学博士学位。2012-2018于欧美剧情av 从事科研助理和博士后研究。2018年起于欧美剧情av 任职青年副研究员，2024年12月任副研究员。

主持国家自然科学基金委青年科学基金项目和面上项目。

招生专业：

长期招收生物信息学和进化遗传学专业研究生。

代表性论文和论著：

1.         Zheng HX†#, Yan S, Zhang M, Gu Z, Wang J, Jin L#. Mitochondrial DNA Genomes Reveal Relaxed Purifying Selection During Human Population Expansion after the Last Glacial Maximum. Molecular Biology and Evolution, 2024;41(9):msae175.

2.         Chen Z†, Chen L†, Tan J†, Mao Y, Hao M, Li Y, Wang Y, Li J, Wang J#, Jin L#, Zheng HX#. Natural selection shaped the protective effect of the mtDNA lineage against obesity in Han Chinese populations. Journal of Genetics and Genomics. 2024, S1673-8527(24)00129-2.

3.         Tao Y†, Wei Y†, Ge J†, Pan Y†, Wang W, Bi Q, Sheng P, Fu C, Pan W, Jin L, Zheng HX#, Zhang M#. Phylogenetic evidence reveals early Kra-Dai divergence and dispersal in the late Holocene. Nature Communications. 2023 Oct 30;14(1):6924.

4.         Ning C†, Zheng HX†, Zhang F†, Wu S, Li C, Zhao Y, Xu Y, Wei D, Wu Y, Gao S*, Jin L*, Cui Y*. Ancient Mitochondrial Genomes Reveal Extensive Genetic Influence of the Steppe Pastoralists in Western Xinjiang. Frontiers in Genetics. 2021 ,12:740167.

5.         Sun D†, Niu Z†, Zheng HX†, Wu F, Jiang L, Han TQ, Wei Y, Wang J*, Jin L*. A mitochondrial DNA variant elevates the risk of gallstone disease by altering mitochondrial function. Cellular and Molecular Gastroenterology and Hepatology, 2021;11(4):1211-1226.e15.

6.         Zhang M†, Zheng HX†, Yan S*, Jin L*. Reconciling the father tongue and mother tongue hypotheses in Indo-European populations. National Science Review, 2019, 6(2):293-300.

7.         He L†, Zheng HX†, Wang Y, Le KY, Liu Q, Shang J, Dai Y, Meng H, Wang X, Li T, Gao Q, Qin J, Lu H, Otto M*, Li M*. Detection and analysis of methicillin-resistant human-adapted sequence type 398 allows insight into community-associated methicillin-resistant Staphylococcus aureus evolution. Genome Medicine, 2018, 10(1):5.

8.         Zheng HX†, Li L†, Jiang XY†, Yan S, Qin Z, Wang X*, Jin L*. MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population. Human Genetics, 2017,136(10):1353-1362.

9.         Kang L†*, Zheng HX†, Zhang M, Yan S, Li L, Liu L, Liu K, Hu K, Chen F, Ma L, Qin Z, Wang Y, Wang X, Jin L*. MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders. Scientific Reports, 2016, 6:31083.

10.     Yin M†, Zheng HX†, Su J, Feng Z, McManus DP, Zhou XN, Jin L, Hu W*. Co-dispersal of the blood fluke Schistosoma japonicum and Homo sapiens in the Neolithic Age. Scientific Reports, 2015, 5:18058.

11.     Kang L†*, Zheng HX†, Chen F, Yan S, Liu K, Qin Z, Liu L, Zhao Z, Li L, Wang X, He Y, Jin L*. mtDNA lineage expansions in Sherpa population suggest adaptive evolution in Tibetan highlands. Molecular Biology and Evolution, 2013, 30(12):2579-87.

12.     Zheng HX, Yan S, Qin ZD, Jin L*. MtDNA analysis of global populations support that major population expansions began before Neolithic Time. Scientific Reports, 2012, 2:745.

13.     Zheng HX†, Yan S†, Qin ZD, Wang Y, Tan JZ, Li H, Jin L*. Major population expansion of East Asians began before Neolithic Time: Evidence of mtDNA genomes. PLoS One, 2011, 6(10):e25835.